Integrative & Computational Systems Immunology

Patterns, Microbes, Sensors & Disease

We are interested in investigating pattern-recognition molecules, sensors monitoring cellular states, communication circuits and how these function as integrated systems in innate immunity, autophagy and disease. We utilize integrative systems approaches involving computation and high-throughput experimentation (RNA interference (RNAi) and chemical biology screens, transcriptomics, proteomics, metabolomics, and data from genome-wide association studies (GWAS)) to investigate the underlying signaling pathways and regulatory networks that define host-microbial interactions, inflammation, autophagy and pathogenesis of complex immunological diseases including Crohn’s disease and ulcerative colitis.

The lab is in the Division of Gastroenterology in the Department of Medicine and also in the Center for the Study of Inflammatory Bowel Disease (CSIBD) at Massachusetts General Hospital and Harvard Medical School.